Regulation of odontogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of odontogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SP6, CSF1, and CFAP52, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SP6 grouped by Regulation of odontogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SP6 →	-0.262	-1.064	<.001	<.001	3	5
KIDNEY	CSF1 →	-0.305	-1.425	<.001	<.001	3	5
LIVER	CFAP52 →	-0.281	-1.493	.002	.005	3	4
OVARY	SLC27A2 →	-0.258	-1.278	.003	.004	3	4
OVARY	ZNF24 →	+0.173	+1.305	<.001	<.001	3	4
BLOOD_Leukemia	PRSS55 →	-0.113	-1.422	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SP6 by Regulation of odontogenesis activity — OVARY

Explore this box plot interactively →