Regulation of odontogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of odontogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPS, ACAP3, and CLDND2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CENPS grouped by Regulation of odontogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CENPS →	+0.815	+1.217	<.001	.003	3	4
LIVER	ACAP3 →	-0.937	-1.533	.001	.005	3	4
KIDNEY	CLDND2 →	+1.127	+1.843	.002	<.001	3	4
BONE	PPARD →	-0.903	-1.394	.004	.002	3	4
BONE	REXO2 →	-0.706	-1.618	.009	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF160 →	-2.226	-1.492	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CENPS by Regulation of odontogenesis activity — LUNG_SCLC

Explore this box plot interactively →