Odontogenesis

Across TCGA cell cohorts, RNA activity of the Odontogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1B, CAPN14, and MRPL44, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Odontogenesis activity versus POLR1B in BONE (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	POLR1B →	-0.957	-0.478	.009	<.001	3	6
BLOOD_Leukemia	CAPN14 →	+0.468	+0.287	.004	.006	3	5
OESOPHAGUS	MRPL44 →	-0.662	-0.277	.004	.006	2	6
BLOOD_Leukemia	TBC1D10A →	+1.085	+0.234	<.001	.005	3	5
UPPER_AERODIGESTIVE_TRACT	DHODH →	-0.647	-0.251	.005	.004	2	6
CNS	MAGEH1 →	+1.309	+0.251	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042476 vs POLR1B — BONE

Explore this scatter interactively →