Odontogenesis of dentin-containing tooth

Across TCGA patient cohorts, RNA activity of the Odontogenesis of dentin-containing tooth pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL1A2, SULF1, and LTBP3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Odontogenesis of dentin-containing tooth activity versus COL1A2 in GBM (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL1A2 →	+0.688	+0.034	.003	<.001	3	9
CCRCC	SULF1 →	+0.795	+0.023	<.001	.006	2	9
OV	LTBP3 →	+0.396	+0.036	.007	.001	3	8
PDAC	IGFBP7 →	+0.640	+0.040	<.001	<.001	3	8
UCEC	THBS2 →	+0.830	+0.035	.004	.003	3	7
GBM	SERPINE1 →	+1.081	+0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042475 vs COL1A2 — GBM

Explore this scatter interactively →