Odontogenesis of dentin-containing tooth

Across TCGA patient cohorts, RNA activity of the Odontogenesis of dentin-containing tooth pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ULBP2, GALNT1, and CXCL14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Odontogenesis of dentin-containing tooth activity versus ULBP2 in LSCC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ULBP2 →	+0.867	+0.864	.007	.005	3	4
BRCA	GALNT1 →	+0.501	+0.635	.001	<.001	3	4
UCEC	CXCL14 →	+1.933	+0.905	.002	<.001	3	3
LSCC	SGK1 →	+0.883	+0.845	<.001	<.001	3	3
COAD	MCC →	+0.362	+0.572	.004	.007	3	3
UCEC	UPK3BP1 →	+0.465	+0.550	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042475 vs ULBP2 — LSCC

Explore this scatter interactively →