Odontogenesis of dentin-containing tooth

Across TCGA cell cohorts, RNA activity of the Odontogenesis of dentin-containing tooth pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM18, ACVR2A, and CSF2RA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM18 grouped by Odontogenesis of dentin-containing tooth-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RBM18 →	-0.458	-1.648	.002	.002	3	5
OVARY	ACVR2A →	-0.354	-1.221	.001	<.001	3	4
OESOPHAGUS	CSF2RA →	-0.232	-0.410	.005	.001	3	4
SKIN	AMPD3 →	-0.161	-0.617	.007	.008	3	3
LIVER	FERMT2 →	+0.673	+1.380	<.001	.006	3	3
CNS	GIT1 →	-0.128	-0.631	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM18 by Odontogenesis of dentin-containing tooth activity — LIVER

Explore this box plot interactively →