Odontogenesis of dentin-containing tooth

Across TCGA cell cohorts, RNA activity of the Odontogenesis of dentin-containing tooth pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOP3A, CCNI, and IL13RA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOP3A grouped by Odontogenesis of dentin-containing tooth-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TOP3A →	+0.894	+0.245	.004	.003	3	4
UPPER_AERODIGESTIVE_TRACT	CCNI →	-0.706	-0.784	.008	.006	3	3
SKIN	IL13RA1 →	-0.703	-0.775	.009	.002	3	3
LARGE_INTESTINE	PKMYT1 →	+0.507	+0.641	.002	.002	3	3
LARGE_INTESTINE	SERTAD1 →	+1.018	+1.051	.001	<.001	3	3
LARGE_INTESTINE	TYMP →	+1.102	+0.810	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOP3A by Odontogenesis of dentin-containing tooth activity — BLOOD_Leukemia

Explore this box plot interactively →