Odontogenesis of dentin-containing tooth

Across TCGA cell cohorts, RNA activity of the Odontogenesis of dentin-containing tooth pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1B, NTN4, and PEDS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Odontogenesis of dentin-containing tooth activity versus POLR1B in PANCREAS (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	POLR1B →	-0.665	-0.365	.008	<.001	3	6
BONE	NTN4 →	+2.243	+0.238	.004	.002	3	6
LARGE_INTESTINE	PEDS1 →	+0.872	+0.213	.005	.006	3	5
OESOPHAGUS	MRPL24 →	-0.778	-0.385	.004	<.001	3	5
LUNG_NSCLC_LUAD	CHMP4B →	+0.767	+0.345	<.001	.004	3	4
URINARY_TRACT	RSAD1 →	-1.032	-0.237	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042475 vs POLR1B — PANCREAS

Explore this scatter interactively →