Middle ear morphogenesis

Across TCGA patient cohorts, RNA activity of the Middle ear morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCYOX1, DCHS1, and ALOX5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Middle ear morphogenesis activity versus PCYOX1 in OV (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PCYOX1 →	+0.352	+0.046	.005	.001	3	6
OV	DCHS1 →	+0.397	+0.053	.003	.001	3	5
CCRCC	ALOX5 →	-0.474	-0.049	.003	.003	3	5
HNSC	SASH3_S97 →	-0.643	-0.049	<.001	.001	3	5
GBM	PCDH7_S1011 →	+0.606	+0.052	<.001	<.001	3	5
BRCA	MACROH2A1_T129 →	-0.388	-0.036	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042474 vs PCYOX1 — OV

Explore this scatter interactively →