Middle ear morphogenesis

Across TCGA patient cohorts, RNA activity of the Middle ear morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTN-AS1, RN7SKP24, and GLDCP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Middle ear morphogenesis activity versus TTN-AS1 in LSCC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TTN-AS1 →	+0.288	+0.608	.001	.003	3	3
UCEC	RN7SKP24 →	-1.886	-0.662	<.001	<.001	3	3
BRCA	GLDCP1 →	-0.452	-0.521	.002	.003	3	3
GBM	CEP41 →	-0.335	-0.699	.008	.001	3	3
GBM	RARA →	+0.342	+0.648	.003	.004	3	3
HNSC	ARMCX4 →	+0.423	+0.627	<.001	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042474 vs TTN-AS1 — LSCC

Explore this scatter interactively →