Middle ear morphogenesis

Across TCGA cell cohorts, RNA activity of the Middle ear morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF155, SUMF1, and DUSP8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF155 grouped by Middle ear morphogenesis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZNF155 →	-0.745	-0.847	.009	.005	3	5
UPPER_AERODIGESTIVE_TRACT	SUMF1 →	-1.766	-1.403	.006	.008	3	5
LIVER	DUSP8 →	-1.525	-1.334	.001	<.001	3	5
SOFT_TISSUE	TIAM1 →	+1.909	+1.384	<.001	.001	3	4
STOMACH	FOSL2 →	-1.987	-1.179	.002	.001	3	4
BONE	ABR →	-1.571	-1.559	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF155 by Middle ear morphogenesis activity — KIDNEY

Explore this box plot interactively →