Ear morphogenesis

Across TCGA cell cohorts, RNA activity of the Ear morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3RF3, REEP6, and ZNF706, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SH3RF3 grouped by Ear morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SH3RF3 →	-0.790	-0.349	.003	.008	3	4
BLOOD_Leukemia	REEP6 →	+1.610	+0.935	<.001	.002	3	3
BLOOD_Leukemia	ZNF706 →	+0.799	+1.428	<.001	<.001	3	3
BLOOD_Leukemia	OCLN →	+1.083	+0.916	<.001	.002	3	3
SOFT_TISSUE	SDK1 →	-1.747	-0.254	<.001	.002	3	3
URINARY_TRACT	MTR →	-0.734	-1.411	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SH3RF3 by Ear morphogenesis activity — BREAST

Explore this box plot interactively →