Ear morphogenesis

Across TCGA cell cohorts, RNA activity of the Ear morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPY19L1, RNH1, and PTPN14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ear morphogenesis activity versus DPY19L1 in BLOOD_Lymphoma (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DPY19L1 →	-1.771	-0.379	<.001	<.001	3	4
URINARY_TRACT	RNH1 →	-1.163	-0.286	<.001	<.001	3	4
PANCREAS	PTPN14 →	-1.616	-0.920	<.001	.004	3	4
LARGE_INTESTINE	PTPN12 →	-0.682	-0.166	.001	.002	3	4
STOMACH	PIAS3 →	-1.720	-0.322	.003	.002	3	4
BLOOD_Lymphoma	SFXN3 →	-2.395	-0.326	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042471 vs DPY19L1 — BLOOD_Lymphoma

Explore this scatter interactively →