Eye photoreceptor cell development

Across TCGA patient cohorts, RNA activity of the Eye photoreceptor cell development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RUVBL2, SMAP2, and SEPTIN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye photoreceptor cell development activity versus RUVBL2 in GBM (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RUVBL2 →	+0.225	+0.039	.003	.009	3	5
GBM	SMAP2 →	-0.345	-0.062	<.001	<.001	3	5
LSCC	SEPTIN1 →	-0.636	-0.050	.001	<.001	3	5
LSCC	ACSL5 →	-0.610	-0.051	<.001	<.001	3	5
BRCA	TRAF1 →	-0.494	-0.032	.001	<.001	3	5
HNSC	CD74 →	-0.533	-0.039	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042462 vs RUVBL2 — GBM

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