Eye photoreceptor cell development

Across TCGA cell cohorts, RNA activity of the Eye photoreceptor cell development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D9B, RSPH9, and CTU2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D9B grouped by Eye photoreceptor cell development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TBC1D9B →	-0.726	-1.742	<.001	<.001	3	4
LUNG_SCLC	RSPH9 →	+0.383	+1.040	.001	.004	3	4
LUNG_SCLC	CTU2 →	-0.761	-1.481	.001	<.001	3	4
BLOOD_Myeloma	IFIT5 →	-1.021	-1.489	.003	<.001	3	4
BLOOD_Leukemia	TRIM3 →	-1.261	-1.170	.002	.007	3	4
BREAST	PDLIM2 →	+1.017	+0.728	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D9B by Eye photoreceptor cell development activity — LIVER

Explore this box plot interactively →