Eye photoreceptor cell development

Across TCGA cell cohorts, RNA activity of the Eye photoreceptor cell development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC6, LRRC8A, and SMYD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC6 grouped by Eye photoreceptor cell development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCDC6 →	-0.230	-0.202	.001	.003	3	4
BLOOD_Leukemia	LRRC8A →	-0.176	-0.221	.002	<.001	3	3
BLOOD_Leukemia	SMYD2 →	+0.150	+0.234	.005	.002	2	4
LUNG_NSCLC_LUAD	MYO5A →	-0.141	-0.238	.003	<.001	2	4
LUNG_NSCLC_LUAD	ARHGDIG →	-0.198	-0.221	.001	.001	2	4
LUNG_SCLC	PRDM2 →	+0.228	+0.232	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC6 by Eye photoreceptor cell development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →