Eye photoreceptor cell development

Across TCGA cell cohorts, RNA activity of the Eye photoreceptor cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12C, RETREG2, and TMEM127, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Eye photoreceptor cell development activity versus PPP1R12C in LUNG_NSCLC_LUAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPP1R12C →	+0.376	+0.142	.004	.004	3	6
SOFT_TISSUE	RETREG2 →	+0.398	+0.254	.007	.006	3	4
SOFT_TISSUE	TMEM127 →	+0.514	+0.167	<.001	.008	3	4
KIDNEY	LMBR1L →	+1.044	+0.332	.009	.001	3	3
LUNG_NSCLC_LUAD	MBOAT7 →	+0.722	+0.136	.004	.006	3	3
LUNG_NSCLC_LUAD	B4GALT5 →	+0.861	+0.185	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042462 vs PPP1R12C — LUNG_NSCLC_LUAD

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