Photoreceptor cell development

Across TCGA patient cohorts, RNA activity of the Photoreceptor cell development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPAG1_S418, TRAF3IP1, and FSCN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoreceptor cell development activity versus SPAG1_S418 in LUAD (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPAG1_S418 →	+0.672	+0.028	.007	.006	3	5
BRCA	TRAF3IP1 →	+0.349	+0.022	<.001	<.001	3	5
BRCA	FSCN1 →	-0.488	-0.026	.003	.001	3	5
BRCA	MSI2 →	+0.503	+0.032	<.001	<.001	3	5
GBM	MAP1S →	-0.163	-0.046	.001	<.001	3	5
BRCA	GIMAP8 →	-0.252	-0.016	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042461 vs SPAG1_S418 — LUAD

Explore this scatter interactively →