Photoreceptor cell development

Across TCGA patient cohorts, RNA activity of the Photoreceptor cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RACGAP1, MELK, and PPP1R16B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoreceptor cell development activity versus RACGAP1 in BRCA (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RACGAP1 →	-0.547	-0.515	.003	.003	3	4
OV	MELK →	-1.148	-0.695	<.001	.002	3	4
GBM	PPP1R16B →	+1.442	+0.347	<.001	.004	3	3
COAD	KIF18A →	-0.555	-0.278	<.001	.003	3	3
CCRCC	SSTR1 →	+0.688	+0.482	<.001	<.001	3	3
CCRCC	SLC22A15 →	-0.666	-0.425	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042461 vs RACGAP1 — BRCA

Explore this scatter interactively →