Photoreceptor cell development

Across TCGA patient cohorts, RNA activity of the Photoreceptor cell development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM14C, CTDP1_S474, and SCRN2_T52, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoreceptor cell development activity versus TMEM14C in LSCC (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMEM14C →	+0.649	+0.713	<.001	<.001	3	3
OV	CTDP1_S474 →	-3.146	-0.844	<.001	<.001	3	3
BRCA	SCRN2_T52 →	+1.260	+1.140	<.001	<.001	3	3
UCEC	ZC3HC1_S335 →	-0.382	-0.666	.003	<.001	3	3
OV	DLGAP5_S806 →	-0.647	-0.698	<.001	<.001	3	3
BRCA	IFT140 →	+0.360	+0.599	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042461 vs TMEM14C — LSCC

Explore this scatter interactively →