Photoreceptor cell development

Across TCGA cell cohorts, RNA activity of the Photoreceptor cell development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSME1, ADNP2, and H2BC11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSME1 grouped by Photoreceptor cell development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PSME1 →	-1.014	-0.889	<.001	.005	3	4
LUNG_NSCLC_LUSC	ADNP2 →	+1.073	+1.592	.004	.002	3	4
LUNG_SCLC	H2BC11 →	-2.228	-1.260	.003	<.001	3	4
LARGE_INTESTINE	NARS2 →	+0.544	+1.074	.004	<.001	3	4
LIVER	TAS2R20 →	+0.339	+1.191	.001	.007	3	4
BONE	SLC43A1 →	+1.702	+2.023	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSME1 by Photoreceptor cell development activity — BLOOD_Leukemia

Explore this box plot interactively →