Photoreceptor cell development

Across TCGA cell cohorts, RNA activity of the Photoreceptor cell development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GAT1, SCML1, and PTOV1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoreceptor cell development activity versus B4GAT1 in BLOOD_Lymphoma (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	B4GAT1 →	+0.799	+0.171	.001	.002	3	4
OVARY	SCML1 →	-1.585	-0.340	.001	.001	3	4
BLOOD_Lymphoma	PTOV1 →	+0.695	+0.278	.001	<.001	3	3
LUNG_NSCLC_LUAD	PRPF31 →	+0.577	+0.164	.001	.003	3	3
LUNG_NSCLC_LUAD	IQCE →	+0.645	+0.146	.006	.001	2	4
LUNG_NSCLC_LUAD	SCAF1 →	+0.593	+0.176	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042461 vs B4GAT1 — BLOOD_Lymphoma

Explore this scatter interactively →