Ribonucleoside catabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH4, CD244, and CD53, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside catabolic process activity versus CYTH4 in UCEC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYTH4 →	+0.654	+0.188	<.001	<.001	3	7
UCEC	CD244 →	+0.807	+0.283	<.001	<.001	3	7
UCEC	CD53 →	+0.773	+0.153	<.001	.001	3	7
COAD	GFI1 →	+0.702	+0.178	.004	<.001	3	7
UCEC	ARHGAP25 →	+0.694	+0.220	<.001	<.001	3	7
COAD	TRAV13-1 →	+0.892	+0.171	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042454 vs CYTH4 — UCEC

Explore this scatter interactively →