Ribonucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPD, CTSD, and ANKRD46, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPD grouped by Ribonucleoside catabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CPD →	+1.209	+1.170	.003	.006	3	4
OVARY	CTSD →	+1.274	+1.059	.002	.005	3	4
SKIN	ANKRD46 →	-0.509	-1.077	.005	<.001	3	3
STOMACH	TMEM89 →	+0.186	+0.495	.007	.002	3	3
LUNG_SCLC	CALD1 →	+3.875	+1.247	<.001	.001	3	3
BLOOD_Leukemia	ADAM15 →	+2.089	+1.552	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPD by Ribonucleoside catabolic process activity — OVARY

Explore this box plot interactively →