Ribonucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAMP1, MILR1, and LTBP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside catabolic process activity versus SCAMP1 in OVARY (Pearson r = -0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SCAMP1 →	-1.299	-1.814	<.001	<.001	3	4
LARGE_INTESTINE	MILR1 →	-2.009	-1.790	.002	<.001	3	4
LARGE_INTESTINE	LTBP3 →	-2.097	-1.450	.002	<.001	3	3
OESOPHAGUS	PARP14 →	-1.544	-1.506	.006	.002	3	3
SOFT_TISSUE	DHRS12 →	-1.424	-1.543	.003	.001	3	3
STOMACH	CDC37 →	+1.134	+1.679	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042454 vs SCAMP1 — OVARY

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