Progesterone metabolic process

Across TCGA patient cohorts, RNA activity of the Progesterone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1B10, DHRS9, and AKR1C2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Progesterone metabolic process activity versus AKR1B10 in LUAD (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKR1B10 →	+2.085	+0.087	<.001	.001	3	7
PDAC	DHRS9 →	+1.069	+0.092	<.001	<.001	3	6
UCEC	AKR1C2 →	+2.332	+0.117	<.001	<.001	3	6
LSCC	AKR1C3 →	+1.829	+0.146	<.001	<.001	3	6
COAD	UGT1A10 →	+0.882	+0.052	<.001	.001	3	5
LUAD	TALDO1 →	+0.389	+0.099	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042448 vs AKR1B10 — LUAD

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