Progesterone metabolic process

Across TCGA cell cohorts, RNA activity of the Progesterone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A23, FAM207A, and RBM27, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A23 grouped by Progesterone metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC22A23 →	-1.561	-1.277	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	FAM207A →	+1.343	+1.357	.003	.004	3	4
LUNG_NSCLC_LUAD	RBM27 →	+0.429	+1.152	<.001	<.001	3	4
BREAST	NOD1 →	+0.690	+0.636	<.001	.002	3	4
LUNG_SCLC	MRI1 →	+0.572	+0.892	.001	.004	3	3
OVARY	FOXO3 →	-0.810	-1.015	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A23 by Progesterone metabolic process activity — OVARY

Explore this box plot interactively →