Progesterone metabolic process

Across TCGA cell cohorts, RNA activity of the Progesterone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PADI1, COL4A2, and SSBP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Progesterone metabolic process activity versus PADI1 in OVARY (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PADI1 →	-4.687	-0.345	.007	.004	3	3
OVARY	COL4A2 →	-5.610	-0.326	.005	.002	3	3
OVARY	SSBP3 →	+2.069	+0.259	.008	.004	3	3
CNS	CASKIN2 →	-0.693	-0.324	.007	.004	3	3
LUNG_NSCLC_LUAD	TRMT10A →	+1.014	+0.600	.004	.001	3	3
BLOOD_Lymphoma	METAP1 →	+0.860	+0.289	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042448 vs PADI1 — OVARY

Explore this scatter interactively →