Hormone catabolic process

Across TCGA patient cohorts, RNA activity of the Hormone catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIO, MME, and SFXN3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone catabolic process activity versus TRIO in LUAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIO →	+0.241	+0.059	<.001	.009	3	8
PDAC	MME →	+0.903	+0.066	<.001	<.001	3	7
UCEC	SFXN3 →	+0.473	+0.070	.002	.009	3	6
HNSC	ASPH →	+0.204	+0.047	.004	.002	3	6
BRCA	LOXL2 →	+0.593	+0.049	<.001	<.001	3	6
HNSC	PON2 →	+0.485	+0.069	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042447 vs TRIO — LUAD

Explore this scatter interactively →