Hormone catabolic process

Across TCGA patient cohorts, RNA activity of the Hormone catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TREM1, SPP1, and SLC16A3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone catabolic process activity versus TREM1 in PDAC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TREM1 →	+1.078	+0.449	<.001	<.001	3	9
HNSC	SPP1 →	+3.115	+1.063	<.001	<.001	3	8
LUAD	SLC16A3 →	+0.821	+0.445	<.001	<.001	3	7
GBM	SLC11A1 →	+0.941	+0.409	<.001	<.001	3	7
PDAC	LINC01705 →	+1.226	+0.393	<.001	.001	3	7
PDAC	LUCAT1 →	+1.135	+0.474	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042447 vs TREM1 — PDAC

Explore this scatter interactively →