Hormone catabolic process

Across TCGA cell cohorts, RNA activity of the Hormone catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF9, DLL1, and ACYP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLF9 grouped by Hormone catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KLF9 →	+0.947	+0.962	<.001	.002	3	4
LUNG_SCLC	DLL1 →	-4.264	-1.298	<.001	.008	3	4
SOFT_TISSUE	ACYP1 →	-0.883	-0.849	.004	.008	3	4
SKIN	PHLDA3 →	+1.290	+0.923	.008	.001	3	4
SKIN	GSPT2 →	+0.881	+1.075	.006	.001	3	4
SOFT_TISSUE	ZNF587B →	+0.615	+1.064	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLF9 by Hormone catabolic process activity — OESOPHAGUS

Explore this box plot interactively →