Hormone catabolic process

Across TCGA cell cohorts, RNA activity of the Hormone catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPA1B, AAMDC, and WNT8A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSPA1B grouped by Hormone catabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HSPA1B →	-0.313	-1.088	.006	.006	3	4
SKIN	AAMDC →	-0.197	-1.655	.006	<.001	3	3
BREAST	WNT8A →	-0.164	-1.071	.006	.004	3	3
BLOOD_Leukemia	CKMT1B →	-0.280	-1.448	.001	<.001	3	3
BLOOD_Lymphoma	GLDN →	+0.213	+1.755	.004	<.001	2	4
LUNG_NSCLC_LUAD	PRM2 →	-0.166	-1.080	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSPA1B by Hormone catabolic process activity — PANCREAS

Explore this box plot interactively →