Hormone catabolic process

Across TCGA cell cohorts, RNA activity of the Hormone catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOC3, MLF2, and PLEKHG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone catabolic process activity versus AOC3 in STOMACH (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AOC3 →	-1.015	-0.956	.001	.006	3	4
SOFT_TISSUE	MLF2 →	-0.587	-0.945	<.001	.006	3	4
LUNG_SCLC	PLEKHG1 →	-1.654	-0.755	<.001	.009	3	4
SOFT_TISSUE	SELENOK →	+0.734	+1.638	.003	.006	3	4
SKIN	MANSC1 →	-1.032	-0.870	.002	.005	3	4
BREAST	MCM6 →	-0.459	-1.041	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042447 vs AOC3 — STOMACH

Explore this scatter interactively →