Hormone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Hormone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCL3_S41, PRPF38B_S529, and RERE_S656, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone biosynthetic process activity versus BCL3_S41 in PDAC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BCL3_S41 →	-0.215	-0.026	.002	.001	3	5
LUAD	PRPF38B_S529 →	-0.422	-0.046	<.001	<.001	3	4
PDAC	RERE_S656 →	-0.187	-0.035	<.001	<.001	3	4
BRCA	SH3KBP1 →	-0.344	-0.033	.005	<.001	3	4
PDAC	SRPX2 →	+0.679	+0.044	<.001	<.001	3	4
PDAC	STAT1 →	-0.365	-0.037	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042446 vs BCL3_S41 — PDAC

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