Hormone biosynthetic process

Across TCGA cell cohorts, RNA activity of the Hormone biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP7, XYLT2, and GPR176, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGFBP7 grouped by Hormone biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IGFBP7 →	-3.273	-0.997	.001	.004	3	5
STOMACH	XYLT2 →	-0.653	-0.932	.009	.003	3	5
LIVER	GPR176 →	-3.474	-1.070	<.001	.006	2	6
LIVER	PLEKHA2 →	-2.233	-1.356	.001	.001	3	5
LIVER	TMEM158 →	-2.935	-1.179	.001	.004	3	5
LIVER	TRIO →	-1.573	-1.151	.001	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFBP7 by Hormone biosynthetic process activity — SKIN

Explore this box plot interactively →