Hormone metabolic process

Across TCGA patient cohorts, RNA activity of the Hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, TREML4, and PHLDB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone metabolic process activity versus SPP1 in GBM (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPP1 →	+1.319	+0.264	<.001	<.001	3	7
GBM	TREML4 →	+0.456	+0.180	.007	.008	3	7
LSCC	PHLDB2 →	+1.213	+0.179	<.001	<.001	3	6
LSCC	AKR1C2 →	+2.930	+0.226	<.001	<.001	3	6
LSCC	AKR1C1 →	+2.766	+0.231	<.001	<.001	3	6
GBM	SPOCK3 →	+1.407	+0.188	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042445 vs SPP1 — GBM

Explore this scatter interactively →