Hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R32, ZNF155, and CCT7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R32 grouped by Hormone metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PPP1R32 →	-0.760	-1.055	.002	.007	3	5
CNS	ZNF155 →	-0.465	-0.762	<.001	<.001	3	4
OESOPHAGUS	CCT7 →	+0.929	+1.195	<.001	.002	3	4
OESOPHAGUS	DPY30 →	+0.636	+1.341	<.001	<.001	3	4
BLOOD_Lymphoma	TTLL1 →	-0.782	-1.514	.001	<.001	3	4
CNS	PODNL1 →	-1.152	-0.619	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R32 by Hormone metabolic process activity — STOMACH

Explore this box plot interactively →