Hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, RPL10A, and RPL24, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone metabolic process activity versus RPL3 in LUNG_SCLC (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPL3 →	-0.550	-0.225	.001	.005	3	6
CNS	RPL10A →	-0.582	-0.241	.006	<.001	3	6
PANCREAS	RPL24 →	-0.559	-0.164	.002	.003	3	5
PANCREAS	NOB1 →	-0.561	-0.169	.004	.002	3	5
PANCREAS	TMEM45B →	+2.477	+0.148	.008	.004	3	5
BLOOD_Leukemia	NCAPD2 →	-0.743	-0.163	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042445 vs RPL3 — LUNG_SCLC

Explore this scatter interactively →