Hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Hormone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPP1, HEXA, and EIF6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hormone metabolic process activity versus TPP1 in SKIN (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TPP1 →	+1.329	+0.206	<.001	<.001	3	7
PANCREAS	HEXA →	+1.675	+0.210	.001	.003	3	7
KIDNEY	EIF6 →	-0.749	-0.300	<.001	<.001	3	7
PANCREAS	GLB1 →	+1.563	+0.282	<.001	<.001	3	7
BONE	PCBP2 →	-0.989	-0.204	.001	.004	3	7
LUNG_NSCLC_LUAD	IDH3G →	+0.544	+0.165	.006	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042445 vs TPP1 — SKIN

Explore this scatter interactively →