Pigment metabolic process

Across TCGA patient cohorts, RNA activity of the Pigment metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC4_S565, CYC1, and CD82, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment metabolic process activity versus HDAC4_S565 in LSCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HDAC4_S565 →	+0.419	+0.025	<.001	.008	3	5
COAD	CYC1 →	-0.182	-0.011	<.001	.004	3	5
LSCC	CD82 →	-0.543	-0.038	<.001	<.001	3	4
LSCC	MAP1B_S1881 →	+1.445	+0.054	<.001	<.001	3	4
HNSC	MAP1B_S2211 →	+0.484	+0.041	<.001	.007	3	4
BRCA	SRRM2_S1103 →	-0.354	-0.022	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042440 vs HDAC4_S565 — LSCC

Explore this scatter interactively →