Pigment metabolic process

Across TCGA patient cohorts, RNA activity of the Pigment metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB, DUSP4, and PACSIN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment metabolic process activity versus TUBB in UCEC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBB →	-0.730	-0.187	<.001	.002	3	5
LUAD	DUSP4 →	-0.850	-0.110	.002	.005	3	5
HNSC	PACSIN1 →	-0.431	-0.121	<.001	.006	2	5
UCEC	MAPRE1 →	-0.395	-0.153	<.001	.001	3	4
UCEC	DHX15 →	-0.409	-0.145	.002	.001	3	4
UCEC	SNRPC →	-0.877	-0.187	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042440 vs TUBB — UCEC

Explore this scatter interactively →