Pigment metabolic process

Across TCGA cell cohorts, RNA activity of the Pigment metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KPNB1, NUDT21, and PGRMC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pigment metabolic process activity versus KPNB1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KPNB1 →	-0.464	-0.206	.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	NUDT21 →	-0.577	-0.217	.003	.001	3	8
BLOOD_Lymphoma	PGRMC1 →	+0.992	+0.208	.001	<.001	3	7
URINARY_TRACT	RAN →	-1.036	-0.180	.002	.007	3	7
UPPER_AERODIGESTIVE_TRACT	PCNA →	-1.393	-0.249	.002	.001	3	7
UPPER_AERODIGESTIVE_TRACT	PUF60 →	-0.905	-0.297	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042440 vs KPNB1 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →