Indole-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Indole-containing compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH2, GHDC, and UTP4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Indole-containing compound biosynthetic process activity versus ALDH2 in OV (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ALDH2 →	+0.804	+0.162	<.001	<.001	3	10
CCRCC	GHDC →	+0.353	+0.188	<.001	<.001	3	7
BRCA	UTP4 →	-0.359	-0.141	<.001	<.001	3	7
LSCC	CMSS1 →	-0.520	-0.227	<.001	<.001	3	7
BRCA	CRYL1 →	+0.381	+0.114	.005	.008	3	7
BRCA	DNTTIP2 →	-0.261	-0.159	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042435 vs ALDH2 — OV

Explore this scatter interactively →