Indole-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Indole-containing compound biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, POLI, and TAOK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN1 grouped by Indole-containing compound biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TLN1 →	-0.312	-1.621	.005	.002	3	5
BONE	POLI →	-0.200	-0.121	.008	.004	3	4
LUNG_NSCLC_LUSC	TAOK1 →	+0.160	+0.099	.008	.008	3	4
OESOPHAGUS	SLC25A24 →	+0.116	+0.148	.002	.002	3	4
STOMACH	TUT4 →	-0.289	-2.781	<.001	<.001	3	4
LIVER	MYO15A →	+0.196	+1.601	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN1 by Indole-containing compound biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →