Serotonin metabolic process

Across TCGA patient cohorts, RNA activity of the Serotonin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B6, POGZ, and CBX3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin metabolic process activity versus SF3B6 in BRCA (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SF3B6 →	-0.354	-0.074	<.001	<.001	3	5
BRCA	POGZ →	-0.290	-0.058	<.001	<.001	3	5
GBM	CBX3 →	-0.394	-0.064	<.001	<.001	3	5
OV	COIL_T303 →	-0.795	-0.042	.001	.003	3	5
GBM	SF3B3 →	-0.246	-0.073	.005	<.001	3	5
GBM	ATP7A →	+0.261	+0.051	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042428 vs SF3B6 — BRCA

Explore this scatter interactively →