Serotonin metabolic process

Across TCGA cell cohorts, RNA activity of the Serotonin metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDC, HTR1A, and SRD5A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDC grouped by Serotonin metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DDC →	-0.331	-0.851	.003	.003	3	7
CNS	HTR1A →	-0.233	-0.292	<.001	<.001	3	5
LUNG_SCLC	SRD5A1 →	-0.311	-1.117	<.001	.006	3	5
STOMACH	ALDH2 →	-0.356	-1.297	<.001	<.001	3	5
OVARY	RAB42 →	+0.164	+0.731	.001	.008	3	4
BREAST	BRCA1 →	+0.195	+0.996	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDC by Serotonin metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →