Serotonin metabolic process

Across TCGA cell cohorts, RNA activity of the Serotonin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B2M, RPL34, and ERBB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, B2M grouped by Serotonin metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	B2M →	+1.275	+1.244	<.001	<.001	3	5
STOMACH	RPL34 →	+0.718	+1.443	.005	.005	2	5
KIDNEY	ERBB2 →	+1.187	+1.471	.004	.002	3	4
BREAST	RPL24 →	+0.784	+0.991	<.001	.002	3	4
OVARY	KCNMB3 →	-0.816	-0.729	.002	.005	3	4
OESOPHAGUS	KLHL2 →	+0.961	+1.248	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

B2M by Serotonin metabolic process activity — OESOPHAGUS

Explore this box plot interactively →