Serotonin metabolic process

Across TCGA cell cohorts, RNA activity of the Serotonin metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATA4, VTI1B, and RWDD2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GATA4 grouped by Serotonin metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GATA4 →	+0.340	+0.481	.006	.004	3	4
STOMACH	VTI1B →	-0.167	-0.432	.002	.009	3	2
BREAST	RWDD2A →	+0.168	+0.547	.004	.005	3	2
BREAST	ACCS →	+0.156	+0.388	.006	.008	3	2
OESOPHAGUS	CCR5 →	+0.175	+1.235	.003	.002	3	2
OESOPHAGUS	RAB3B →	-0.230	-1.159	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GATA4 by Serotonin metabolic process activity — SKIN

Explore this box plot interactively →