Serotonin metabolic process

Across TCGA cell cohorts, RNA activity of the Serotonin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2G, RLN2, and CCDC74B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin metabolic process activity versus POLR2G in OESOPHAGUS (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	POLR2G →	+0.966	+1.243	.003	.003	3	3
LARGE_INTESTINE	RLN2 →	+0.873	+0.475	<.001	.008	3	3
BREAST	CCDC74B →	+1.626	+0.464	.004	<.001	3	3
BREAST	KMT5A →	+0.639	+0.505	.006	.009	3	3
BREAST	SLX4 →	+0.762	+0.630	.001	.005	3	3
CNS	TNFSF9 →	-3.974	-1.714	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042428 vs POLR2G — OESOPHAGUS

Explore this scatter interactively →