Norepinephrine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Norepinephrine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2, ILK, and KANK2_S540, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Norepinephrine biosynthetic process activity versus FERMT2 in OV (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FERMT2 →	+0.521	+0.541	<.001	<.001	3	6
OV	ILK →	+0.428	+0.600	.001	.001	3	6
LSCC	KANK2_S540 →	+0.479	+0.336	.003	.006	3	6
LSCC	APBB2 →	+0.359	+0.437	.001	.001	3	6
LSCC	MYLK →	+0.595	+0.577	<.001	<.001	3	6
LSCC	PRKD1 →	+0.295	+0.367	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042421 vs FERMT2 — OV

Explore this scatter interactively →